Clinical Benefits of Hepatic Arterial Infusion Chemotherapy for Advanced Hepatocellular Carcinoma

Applied Sciences

Takuro Hisanaga¹  Tsuyoshi Ishikawa¹  Ryo Sasaki¹  Yurika Kotoh-Yamauchi¹  Takashi Matsuda¹  Norikazu Tanabe¹  Issei Saeki¹  Taro Takami¹  Takashi Oono¹  Isao Hidaka¹  Isao Sakaida¹  Takahiro Yamasaki²  Yutaka Suehiro²  Toshihiko Matsumoto² 

[1] Department of Gastroenterology and Hepatology, Graduate School of Medicine, Yamaguchi University, Ube, Yamaguchi 755-8505, Japan;Department of Oncology and Laboratory Medicine, Graduate School of Medicine, Yamaguchi University, Ube, Yamaguchi 755-8505, Japan;

关键词: advanced hepatocellular carcinoma;    hepatic arterial infusion chemotherapy;    sorafenib;    vascular invasion;   

DOI  :  10.3390/app11041882

来源: DOAJ

【 摘 要 】

Recent success of systemic therapeutic agents, including combination immunotherapy, could promote a change in the treatment strategy in patients with advanced hepatocellular carcinoma (HCC). Although hepatic arterial infusion chemotherapy (HAIC) is a treatment option for advanced HCC in Japan, it is not recommended by other guidelines. We discuss the clinical benefits of HAIC compared to sorafenib. The clinical benefits of HAIC are as follows: 1) even a patient with Child–Pugh B HCC (7 or 8 points) is a candidate for HAIC; 2) Child–Pugh scores barely decline with the use of HAIC compared with sorafenib; 3) HAIC is highly effective in patients with vascular invasion compared with sorafenib; and 4) survival in patients receiving HAIC may not be associated with skeletal muscle volume. In contrast, the disadvantages are problems related with the reservoir system. HAIC has clinical benefits in a subpopulation of patients without extrahepatic metastasis with Child–Pugh A HCC and vascular invasion (especially primary branch invasion or main portal vein invasion) or with Child–Pugh B HCC.

【 授权许可】

Unknown