Journal of Clinical Medicine | |
Baseline Absolute Lymphocyte Count and ECOG Performance Score Are Associated with Survival in Advanced Non-Small Cell Lung Cancer Undergoing PD-1/PD-L1 Blockade | |
Theresa Westphal1  SimonPeter Gampenrieder1  Florian Huemer1  Richard Greil1  Lukas Weiss1  Gabriel Rinnerthaler1  Bernd Lamprecht2  David Lang2  Hubert Hackl3  Georg Hutarew4  | |
[1] Department of Internal Medicine III with Haematology, Medical Oncology, Haemostaseology, Infectiology and Rheumatology, Oncologic Center, Salzburg Cancer Research Institute-Laboratory for Immunological and Molecular Cancer Research (SCRI-LIMCR), Paracelsus Medical University, 5020 Salzburg, Austria;Department of Pulmonology, Kepler University Hospital, Med Campus III, 4020 Linz, Austria;Division of Bioinformatics, Biocenter, Medical University of Innsbruck, 6020 Innsbruck, Austria;Institute of Pathology, Paracelsus Medical University Salzburg, 5020 Salzburg, Austria; | |
关键词: absolute lymphocyte count; ECOG performance status; immune-checkpoint inhibitor; antibiotics; PD-1/PD-L1; immune-checkpoint blockade; RANK; VEGF; denosumab; | |
DOI : 10.3390/jcm8071014 | |
来源: DOAJ |
【 摘 要 】
Immune-checkpoint blockade in front-line or second-line treatment improves survival in advanced non-small cell lung cancer (aNSCLC) when compared with chemotherapy alone. However, easily applicable predictive parameters are necessary to guide immune-checkpoint inhibition in clinical practice. In this retrospective bi-centric analysis, we investigated the impact of baseline patient and tumor characteristics on clinical outcome in aNSCLC patients treated with programmed cell death protein 1(PD-1)/programmed cell death ligand 1 (PD-L1) inhibitors. Between May 2015 and January 2018, 142 unselected consecutive NSCLC patients received PD-1/PD-L1 inhibitors during the course of disease. In multivariate analysis, we identified the Eastern Cooperative Oncology Group (ECOG) performance status (ECOG > 1 versus ECOG ≤ 1, HR: 3.23, 95%CI: 1.58−6.60, P = 0.001), baseline absolute lymphocyte count (ALC; high: >0.93 × 109/L versus low: ≤ 0.93 × 109/L, HR: 0.38, 95%CI: 0.23−0.62, P < 0.001), prior or concomitant anti-vascular endothelial growth factor (VEGF) targeting therapy (yes versus no, HR: 2.18, 95%CI: 1.15−4.14, P = 0.017) and TNM stage (IV versus III, HR: 4.18, 95%CI: 1.01−17.36, P = 0.049) as the most relevant parameters for survival. Neither antibiotic exposure (antibiotic-positive versus antibiotic-negative, HR: 0.90, 95%CI: 0.56−1.45, P = 0.675), nor PD-L1 expression on tumor cells (≥1% versus <1%, HR: 0.68, 95%CI: 0.41−1.13, P = 0.140) was associated with survival. Baseline ECOG performance status and ALC were associated with survival in aNSCLC patients treated with PD-1/PD-L1 inhibitors and assessment of these parameters could be suitable in clinical practice.
【 授权许可】
Unknown