Domain-specific physical activity and the risk of colorectal cancer: results from the Melbourne Collaborative Cohort Study

BMC Cancer

Graham G. Giles¹  Roger L. Milne¹  Dallas R. English¹  Amalia Karahalios¹  Robert J. MacInnis¹  Neville Owen¹  Brigid M. Lynch¹  Shahid Mahmood¹ 

[1] Melbourne School of Population and Global Health, University of Melbourne;

关键词: Survival analysis;    Domain-specific physical activity;    Exercise;    Colon;    Hazard ratio;   

DOI  :  10.1186/s12885-018-4961-x

来源: DOAJ

【 摘 要 】

Abstract Background Physical activity reduces the risk of colorectal cancer (CRC), but the relevant evidence derives primarily from self-reported recreational and occupational activity. Less is known about the contribution of other domains of physical activity, such as transport and household. We examined associations between domain-specific physical activities and CRC risk within the Melbourne Collaborative Cohort Study. Methods Analyses included 23,586 participants who were free from invasive colorectal cancer and had completed the International Physical Activity Questionnaire-Long Form at follow-up 2 (2003–2007). Cox regression, with age as the time metric, was used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for ordinal categories of each physical activity domain. Results Adjusted HRs for the highest versus the lowest categories of physical activity were 0.71 (95% CI: 0.51–0.98; p trend  = 0.03) for recreational activity; 0.80 (95% CI: 0.49–1.28; p trend  = 0.38) for occupational activity; 0.90 (95% CI: 0.68–1.19; p trend  = 0.20) for transport activity; and 1.07 (95% CI: 0.82–1.40; p trend  = 0.46) for household activity. Conclusions Recreational activity was associated with reduced CRC risk. A non-significant, inverse association was observed for occupational activity, whereas no association was found for transport or household domains.

【 授权许可】

Unknown