Recent Advances on the Model, Measurement Technique, and Application of Single Cell Mechanics

International Journal of Molecular Sciences

Hao Shen¹  Lining Sun¹  Liguo Chen¹  Yangjun Wang¹  Jizhu Liu¹  Cihai Dai¹  Mingwei Gu¹  Haibo Huang¹ 

[1] School of Mechanical and Electric Engineering, Jiangsu Provincial Key Laboratory of Advanced Robotics, Soochow University, Suzhou 215123, China;

关键词: single-cell mechanical model;    micropipette aspiration;    microfluidic;    optical tweezers;    atomic force microscope;    disease diagnosis;   

DOI  :  10.3390/ijms21176248

来源: DOAJ

【 摘 要 】

Since the cell was discovered by humans, it has been an important research subject for researchers. The mechanical response of cells to external stimuli and the biomechanical response inside cells are of great significance for maintaining the life activities of cells. These biomechanical behaviors have wide applications in the fields of disease research and micromanipulation. In order to study the mechanical behavior of single cells, various cell mechanics models have been proposed. In addition, the measurement technologies of single cells have been greatly developed. These models, combined with experimental techniques, can effectively explain the biomechanical behavior and reaction mechanism of cells. In this review, we first introduce the basic concept and biomechanical background of cells, then summarize the research progress of internal force models and experimental techniques in the field of cell mechanics and discuss the latest mechanical models and experimental methods. We summarize the application directions of cell mechanics and put forward the future perspectives of a cell mechanics model.

【 授权许可】

Unknown