The Application Status of Nanoscale Cellulose-Based Hydrogels in Tissue Engineering and Regenerative Biomedicine

Frontiers in Bioengineering and Biotechnology

Rui Xie¹  Chenyang Wang¹  Pei Tian¹  Yuqiang Tao¹  Zifan Duan¹  Jin Bai¹  Qinqin Lv² 

[1] School of Chemistry and Chemical Engineering, University of South China, Hengyang, China;The Fourth College of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou, China;

关键词: nanoscale;    cellulose;    hydrogel;    biomedicine;    non-toxic material;   

DOI  :  10.3389/fbioe.2021.732513

来源: DOAJ

【 摘 要 】

As a renewable, biodegradable, and non-toxic material with moderate mechanical and thermal properties, nanocellulose-based hydrogels are receiving immense consideration for various biomedical applications. With the unique properties of excellent skeletal structure (hydrophilic functional groups) and micro-nano size (small size effect), nanocellulose can maintain the three-dimensional structure of the hydrogel to a large extent, providing mechanical strength while ensuring the moisture content. Owing to its unique features, nanocellulose-based hydrogels have made excellent progress in research and development on tissue engineering, drug carriers, wound dressings, development of synthetic organs, 3D printing, and biosensing. This review provides an overview of the synthesis of different types of nanocellulose, including cellulose nanocrystals, cellulose nanofibers, and bacterial nanocellulose, and describes their unique features. It further provides an updated knowledge of the development of nanocellulose-based functional biomaterials for various biomedical applications. Finally, it discusses the future perspective of nanocellulose-based research for its advanced biomedical applications.

【 授权许可】

Unknown