Epinephrine affects motility, and increases adhesion, biofilm and virulence of Pseudomonas aeruginosa H103

Scientific Reports

Julie Hardouin¹  Karine Réhel²  Laure Taupin²  Kelly Biaggini³  Nathalie Connil³  Marc Feuilloley³  Olivier Maillot³  Damien Tortuel³  Mélyssa Cambronel³  Sophie Rodrigues³  Isabelle Rincé⁴  Cécile Muller⁴ 

[1]Laboratoire Polymères, Biopolymères, Surfaces, UMR 6270 CNRS, Plateforme Protéomique, PISSARO, Normandie Université, Université de Rouen

[2]Laboratoire de Biotechnologie et Chimie Marines (LBCM) EA 3884, IUEM, Université de Bretagne-Sud

[3]Laboratoire de Microbiologie Signaux et Microenvironnement (LMSM) EA 4312, Normandie Université – Université de Rouen, Évreux

[4]Unité de Recherche Risques Microbiens (U2RM), EA 4655, UFR des sciences, Normandie Université, Université de Caen

DOI  :  10.1038/s41598-019-56666-7

来源: DOAJ

【 摘 要 】

Abstract Microbial endocrinology has demonstrated for more than two decades, that eukaryotic substances (hormones, neurotransmitters, molecules of the immune system) can modulate the physiological behavior of bacteria. Among them, the hormones/neurotransmitters, epinephrine (Epi) and norepinephrine (NE), released in case of stress, physical effort or used in medical treatment, were shown to be able to modify biofilm formation in various bacterial species. In the present study, we have evaluated the effect of Epi on motility, adhesion, biofilm formation and virulence of Pseudomonas aeruginosa, a bacterium linked to many hospital-acquired infections, and responsible for chronic infection in immunocompromised patients including persons suffering from cystic fibrosis. The results showed that Epi increased adhesion and biofilm formation of P. aeruginosa, as well as its virulence towards the Galleria mellonella larvae in vivo model. Deciphering the sensor of this molecule in P. aeruginosa and the molecular mechanisms involved may help to find new strategies of treatment to fight against this bacterium.

【 授权许可】

Unknown