Electrospun PVA/Bentonite Nanocomposites Mats for Drug Delivery

Materials

Mariola Ferrández-Rives¹  José Antonio Gómez-Tejedor²  José Luis Gómez Ribelles²  Ángela Aurora Beltrán-Osuna³ 

[1] Center for Biomaterials and Tissue Engineering, CBIT, Universitat Politècnica de València, 46022 Valencia, Spain;Center for Biomaterials and Tissue Engineering, CBIT, Universitat Politècnica de València, Networking Research Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), 46022 Valencia, Spain;Grupo de Procesos Químicos y Bioquímicos, Departamento de Ingeniería Química y Ambiental, Universidad Nacional de Colombia-KR 30 45-03, Bogotá 111321, Colombia;

关键词: polyvinyl alcohol;    electrospinning;    crosslinking;    nanoclay;    drug delivery;   

DOI  :  10.3390/ma10121448

来源: DOAJ

【 摘 要 】

Electrospun mats and films of polyvinyl alcohol (PVA) hydrogel are produced for drug delivery. To provide mechanical consistency to the gel a reinforcement by nanoclays is introduced in the polymer matrix. Four different suspensions of nanoparticles in the polymer solution are prepared in an adequate solvent. These suspensions are subjected to an electrospinning process to produce the nanofiber mat, while films are produced by casting. The influence of the process parameters over the nanofibers microstructure is analyzed by scanning electron microscopy (SEM). The effectiveness of nanoclay encapsulation in the nanocomposites is tested by a thermogravimetric analysis. A crosslinking reaction in solution is carried out to prevent the dissolution of the nanocomposites in aqueous media. A model protein (bovine serum albumin, BSA) is absorbed in the nanocomposites to characterize the release kinetics in phosphate-buffered saline (PBS).

【 授权许可】

Unknown