Synthesis and Reactivity of [1,2,4]Triazolo-annelated Quinazolines

Molecules

关键词: triazolo[1,5-a]quinazolines;    thionation;    alkylation;    chlorination;    tetracyclic systems;   

DOI  :  10.3390/molecules15107016

来源: DOAJ

【 摘 要 】

This paper reports the synthesis of phenyl-substituted 2-alkoxy(methylsulfanyl)-1,2,4-triazolo[1,5-a]quinazolines starting from N-cyanoimidocarbonates and substituted hydrazinobenzoic acids as building blocks. Thionation or chlorination of the inherent lactam moiety in the target compounds followed by treatment with multifunctional nucleophiles provided access to a variety of derivatives.

【 授权许可】

Unknown