Hemodynamics analysis of the serial stenotic coronary arteries

BioMedical Engineering OnLine

Wenhua Huang¹  Pengcheng Xu¹  Xiaoqing Wang²  Changnong Peng²  Zhanchao Xian²  Lin Shi³  Defeng Wang³  Yufa Xia⁴  Zhifan Gao⁴  Xin Liu⁴  Heye Zhang⁴  Youbing Yin⁵  Liqun Jiao⁶ 

[1] Department of Anatomy, Guangdong Provincial Key Laboratory of Medical Biomechanics, School of Basic Medical Science, Southern Medical University;Department of Cardiology, Shenzhen Sun Yat-Sen Cardiovascular Hospital;Department of Imaging and Interventional Radiology, Prince Of Wales Hospital, The Chinese University of Hong Kong;Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences;Shenzhen Keya Medical Technology;Xuanwu Hospital, Capital University of Medical Sciences;

关键词: Coronary artery;    Multiple stenoses;    Computer tomography based fractional flow reserve;    Computational fluid dynamics;    Geometric factors;   

DOI  :  10.1186/s12938-017-0413-0

来源: DOAJ

【 摘 要 】

Abstract Coronary arterial stenoses, particularly serial stenoses in a single branch, are responsible for complex hemodynamic properties of the coronary arterial trees, and the uncertain prognosis of invasive intervention. Critical information of the blood flow redistribution in the stenotic arterial segments is required for the adequate treatment planning. Therefore, in this study, an image based non-invasive functional assessment is performed to investigate the hemodynamic significances of serial stenoses. Twenty patient-specific coronary arterial trees with different combinations of stenoses were reconstructed from the computer tomography angiography for the evaluation of the hemodynamics. Our results showed that the computed FFR based on CTA images (FFRCT) pullback curves with wall shear stress (WSS) distribution could provide more effectively examine the physiological significance of the locations of the segmental narrowing and the curvature of the coronary arterial segments. The paper thus provides the diagnostic efficacy of FFRCT pullback curve for noninvasive quantification of the hemodynamics of stenotic coronary arteries with serial lesions, compared to the gold standard invasive FFR, to provide a reliable physiological assessment of significant amount of coronary artery stenosis. Further, we were also able to demonstrate the potential of carrying out virtual revascularization, to enable more precise PCI procedures and improve their outcomes.

【 授权许可】

Unknown