Fabrication and Characterization of Medical Mesh-Nebulizer for Aerosol Drug Delivery

Applied Sciences

Guangsup Cho¹  Sang-Hyub Moon²  Ki Chang Nam²  Bong Joo Park³  Kyong-Hoon Choi³  Su-Kang Park⁴ 

[1] Department of Electrical Biological Physics, Kwangwoon University, 20 Kwangwoongil, Nowon-gu, Seoul 01897, Korea;Department of Medical Engineering, Dongguk University College of Medicine, Gyeonggi-do 10326, Korea;Institute of Biomaterials, Kwangwoon University, 20 Kwangwoongil, Nowon-gu, Seoul 01897, Korea;Medical Device Center, Korea Testing Certification, Gunpo-si, Gyeonggi-do 10326, Korea;

关键词: drug delivery;    mesh nebulizer;    Pd–Ni membrane filter;    aerosol;    biocompatibility;   

DOI  :  10.3390/app8040604

来源: DOAJ

【 摘 要 】

In the field of drug delivery, a nebulizer is a device used to convert liquid drugs into tiny airborne droplets, such as aerosol or a mist form. These fine droplets are delivered to a patient’s lungs and airways and then spread throughout the body via blood vessels. Therefore, nebulization therapy is a highly-effective method compared with existing drug delivery methods. To enhance the curative influence of a drug, this study suggests the use of a new micro-porous mesh nebulizer consisting of a controllable palladium–nickel (Pd–Ni) membrane filter, piezoelectric element, and a cavity in the micro-pump. In this research, we optimize a biocompatible Pd–Ni membrane filter, such that it generated the smallest aerosol particles of various drugs. The pore size of the filter outlet is 4.2 μm ± 0.15 μm and the thickness of the Pd-Ni membrane filter is approximately 41.5 μm. In addition, the Pd–Ni membrane filter has good biocompatibility with normal cells. The result of a spray test with deionized (DI) water indicated that the size of a standard liquid droplet is 4.53 μm. The device has an electrical requirement, with a low power consumption of 2.5 W, and an optimal operation frequency of 98.5 kHz.

【 授权许可】

Unknown