Interpolymer Complexes of Eudragit® Copolymers as Novel Carriers for Colon-Specific Drug Delivery

Polymers

Nikoletta Fotaki¹  AleksandraV. Bukhovets²  RouslanI. Moustafine²  VitaliyV. Khutoryanskiy² 

[1]Department of Pharmacy and Pharmacology, University of Bath, Claverton Down, Bath, BA2 7AY, UK

[2]Institute of Pharmacy, Kazan State Medical University, 16 Fatykh Amirkhan Street, 420012 Kazan, Russian Federation

关键词: interpolymer complexes;    Eudragit^®, indomethacin;    oral drug delivery;    biorelevant media;    controlled drug delivery;    drug delivery systems;   

DOI  :  10.3390/polym12071459

来源: DOAJ

【 摘 要 】

Interpolymer complexes (IPC) based on Eudragit^® EPO and Eudragit^® S100 were investigated as potential carriers for oral controlled drug delivery to the colon. IPC samples were prepared by mixing copolymer solutions in organic solvents (ethanol, isopropanol:acetone mixture (60:40, % v/v) and tetrahydrofuran). According to the data of elemental analysis, FTIR-spectroscopy, X-ray photoelectron spectroscopy and thermal analysis these IPCs have excess of anionic copolymer (Eudragit^® S100) in their structure; they are stabilized by hydrogen and ionic intermacromolecular bonds and do not include free copolymer domains. IPC have pH-independent swelling properties in the media mimicking gastrointestinal tract (GIT) conditions and provide colon-specific delivery of indomethacin in buffer solutions (pH 1.2; 5.8; 6.8; 7.4) and in biorelevant media (fasted state simulated gastric fluid, fasted state simulated intestinal fluid—version 2 and fasted stated simulated colonic fluid).

【 授权许可】

Unknown