The Emergence of HIV-1 Transmitted Drug Resistance Mutations Among Antiretroviral Therapy-naive Individuals in Buleleng, Bali, Indonesia

Acta Medica Indonesiana

Masanori Kameoka¹  Tomohiro Kotaki²  Shuhei Ueda²  Ni Luh Ayu Megasari³  Siti Qamariyah Khairunisa³  Elsa Fitriana³  Devi Oktafiani³  Nasronudin Nasronudin³  Soetjipto Soetjipto⁴ 

[1] Department of Public Health, Kobe University Graduate School of Health Sciences, Hyogo, JapanCenter for Infectious Diseases, Kobe University Graduate School of Medicine, Hyogo, Japan.;Kobe University Graduate School of Health Sciences;Universitas Airlangga;[e-mail];

关键词: hiv-1;    crf01_ae;    bali;    antiretroviral therapy (art);    transmitted drug resistance (tdr);   

DOI  :  

来源: DOAJ

【 摘 要 】

Background: the global scale-up of antiretroviral therapy (ART) is the primary factor contributing to the decline in deaths from acquired immune deficiency syndrome (AIDS)-related illnesses. However, the emergence of transmitted drug resistance (TDR) compromises the effects of ART in treatment-naïve individuals, which may hinder treatment success. The present study aimed to identify the presence of TDR among treatment-naive individuals in Buleleng, Bali, which is currently ranked sixth among Indonesian provinces with the highest cumulative human immunodeficiency virus type 1 (HIV-1) infection cases. Methods: thirty-nine ART-naive individuals in Buleleng Regency General Hospital were enrolled in the present study. Blood samples from participants were subjected to a genotypic analysis. Results: 28 protease (PR) and 30 reverse transcriptase (RT) genes were successfully amplified and sequenced from 37 samples. HIV-1 subtyping revealed CRF01_AE as the dominant circulating recombinant form in the region. No TDR for PR inhibitors was detected; however, TDR for RT inhibitors was identified in five out of 30 samples (16.7%). Conclusion: these results indicate the emergence of TDR among ART-naive individuals in Buleleng, Bali. This issue warrants serious consideration because TDR may hamper treatment success and reduce ART efficacy among newly diagnosed individuals. Continuous surveillance with a larger sample size is necessary to monitor TDR among ART-naive individuals.

【 授权许可】

Unknown