Non-Alcoholic Steatohepatitis in Myotonic Dystrophy: DMPK Gene Mutation, Insulin Resistance and Development of Steatohepatitis

Case Reports in Gastroenterology

关键词: Non-alcoholic steatohepatitis;    Myotonic dystrophy;    DMPK gene mutation;    Insulin resistance;   

DOI  :  10.1159/000292093

来源: DOAJ

【 摘 要 】

Myotonic dystrophy is a multisystemic disorder characterized by repeat expansion mutations of the dystrophia myotonica protein kinase (DMPK) gene resulting in a defective muscular insulin receptor and insulin resistance. We describe a patient with myotonic dystrophy who developed biopsy-proven non-alcoholic steatohepatitis. We suggest that patients with myotonic dystrophy are at risk of developing steatohepatitis. The relationship between defective insulin receptor and development of steatohepatitis should be further investigated.

【 授权许可】

Unknown