Electrochemical Detection of Neurotransmitters

Biosensors

Saikat Banerjee¹  Stephanie McCracken¹  Gymama Slaughter¹  MdFaruk Hossain¹ 

[1] Frank Reidy Research Center for Bioelectrics, Department of Electrical and Computer Engineering, Old Dominion University, Norfolk, VA 23508, USA;

关键词: neurotransmitters;    electrochemical;    biosensors;    fast scan cyclic voltammetry;    differential pulse voltammetry;    cyclic voltammetry;   

DOI  :  10.3390/bios10080101

来源: DOAJ

【 摘 要 】

Neurotransmitters are important chemical messengers in the nervous system that play a crucial role in physiological and physical health. Abnormal levels of neurotransmitters have been correlated with physical, psychotic, and neurodegenerative diseases such as Alzheimer’s, Parkinson’s, dementia, addiction, depression, and schizophrenia. Although multiple neurotechnological approaches have been reported in the literature, the detection and monitoring of neurotransmitters in the brain remains a challenge and continues to garner significant attention. Neurotechnology that provides high-throughput, as well as fast and specific quantification of target analytes in the brain, without negatively impacting the implanted region is highly desired for the monitoring of the complex intercommunication of neurotransmitters. Therefore, it is crucial to develop clinical assessment techniques that are sensitive and reliable to monitor and modulate these chemical messengers and screen diseases. This review focuses on summarizing the current electrochemical measurement techniques that are capable of sensing neurotransmitters with high temporal resolution in real time. Advanced neurotransmitter sensing platforms that integrate nanomaterials and biorecognition elements are explored.

【 授权许可】

Unknown