Multiple endocrine neoplasia type 1 involving both the liver and lung: a case report

World Journal of Surgical Oncology

Hui Cheng¹  Junyi Wu²  Yangyang Huang²  Funan Qiu²  Jianlin Lai² 

[1] Department of Pathology, Fujian Provincial Hospital, Fujian Medical University;Shengli Clinical Medical College of Fujian Medical University;

关键词: Case report;    Liver;    Lung;    Multiple endocrine neoplasia type 1;    Genetic sequencing;   

DOI  :  10.1186/s12957-022-02622-1

来源: DOAJ

【 摘 要 】

Abstract Background Multiple endocrine neoplasia type 1 (MEN1) is a rare autosomal dominant tumor syndrome with a high degree of heterogeneity in clinical phenotypes, generally involving the parathyroid, anterior pituitary, and enteropancreas. In recent years, several new insights into the clinical features of MEN1 have been reported in the literature. However, it is not clear whether MEN1-associated primary tumors can occur in the liver. Case presentation We report the case of a 52-year-old man with multiple endocrine neoplasia type 1 diagnosed by genetic sequencing. After uniportal thoracoscopic right middle lobectomy, laparoscopic radical resection of the liver tumors, and radiofrequency ablation of the parathyroid space, the parathyroid hormone level decreased from 177 pg/ml to a normal level (20 pg/ml). No local tumor recurrence was observed during a follow-up of 5 months. Conclusion We report the first case of MEN1 with simultaneous liver and lung involvement in which the patient underwent radical resection of the tumors, and we propose the possibility that the liver and other nonendocrine organs may also develop diseases associated with MEN1; although, this view needs further verification. Gene detection has crucial clinical significance for guiding diagnosis and treatment.

【 授权许可】

Unknown