Multi-omics reveals microbiome, host gene expression, and immune landscape in gastric carcinogenesis

iScience

Tae Hyun Hwang¹  Changjin Hong²  Chan Hyuk Park³  A-reum Lee³  Jaeyun Sung⁴ 

[1] Division of Surgery Research, Department of Surgery, Mayo Clinic, Rochester, MN 55905, USA;Department of Artificial Intelligence and Informatics, Mayo Clinic, Jacksonville, FL 32224, USA;Department of Internal Medicine, Hanyang University Guri Hospital, Hanyang University College of Medicine, Guri, Gyeonggido 11923, Republic of Korea;Microbiome Program, Center for Individualized Medicine, Mayo Clinic, Rochester, MN 55905, USA;

关键词: Cellular physiology;    Microbiome;    Omics;   

DOI  :  

来源: DOAJ

【 摘 要 】

Summary: To date, there has been no multi-omic analysis characterizing the intricate relationships between the intragastric microbiome and gastric mucosal gene expression in gastric carcinogenesis. Using multi-omic approaches, we provide a comprehensive view of the connections between the microbiome and host gene expression in distinct stages of gastric carcinogenesis (i.e., healthy, gastritis, cancer). Our integrative analysis uncovers various associations specific to disease states. For example, uniquely in gastritis, Helicobacteraceae is highly correlated with the expression of FAM3D, which has been previously implicated in gastrointestinal inflammation. In addition, in gastric cancer but not in adjacent gastritis, Lachnospiraceae is highly correlated with the expression of UBD, which regulates mitosis and cell cycle time. Furthermore, lower abundances of B cell signatures in gastric cancer compared to gastritis may suggest a previously unidentified immune evasion process in gastric carcinogenesis. Our study provides the most comprehensive description of microbial, host transcriptomic, and immune cell factors of the gastric carcinogenesis pathway.

【 授权许可】

Unknown