期刊论文详细信息
Ecotoxicology and Environmental Safety
Association between the total plasma isomers of per- and polyfluoroalkyl substances and erythrograms in young and middle-aged Taiwanese populations
Chikang Wang1  Hui-Ling Lee2  Fung-Chang Sung3  Ta-Chen Su4  Chien-Yu Lin5 
[1] Department of Environmental Engineering and Health, Yuanpei University of Medical Technology, Hsinchu 300, Taiwan;School of Medicine, Fu Jen Catholic University, New Taipei City 242, Taiwan;Department of Chemistry, Fu Jen Catholic University, New Taipei City 242, Taiwan;Department of Environmental Engineering and Health, Yuanpei University of Medical Technology, Hsinchu 300, Taiwan;Department of Internal Medicine, En Chu Kong Hospital, New Taipei City 237, Taiwan;
关键词: Isomers;    Red blood cells;    Erythrogram;    Per- and polyfluoroalkyl substances (PFAS);    Perfluorooctanoic acid (PFOA);    Perfluorooctane sulfonate (PFOS);   
DOI  :  
来源: DOAJ
【 摘 要 】

Purpose: Per- and polyfluoroalkyl substances (PFAS) are human-made chemicals used in daily use products. Recent studies have shown that different perfluorooctanoic acid (PFOA) and/or perfluorooctane sulfonate (PFOS) isomers may have different biological effects. In vitro studies have also reported that PFAS exposure can alter the structure of hemoglobin (Hb). In epidemiology, however, few studies have investigated the relationship between PFAS exposure and erythrocytes. Additionally, the correlation between PFOA/PFOS isomers and full erythrograms has never been explored. Approach and results: In cohorts comprising young and middle-aged Taiwanese populations, we enrolled 1483 participants (aged between 12 and 63 years) to analyze the correlations between the plasma levels of PFOA/PFOS isomers and whole-blood erythrograms. The study comprised 868 men and 615 women with a mean age of 31.2 years. When all PFOA/PFOS isomers were entered into the multiple linear regression model, the linear PFOA (L-PFOA) levels were positively correlated with the Hb, hematocrit (HCT), mean corpuscular volume (MCV), and mean corpuscular hemoglobin (MCH) levels while the branched PFOS (B-PFOS) levels were positively associated with the Hb, HCT, and mean corpuscular hemoglobin concentration (MCHC). The mean value of Hb was the highest (14.66 mg/dL (95% CI =14.52–14.80); P for trend <0.001) when both the L-PFOA and B-PFOS levels were above the 50th percentile. Conclusions: The results imply that PFOA/PFOS isomers may increase the weight and volume of Hb/RBC and that L-PFOA/B-PFOS may have an additive effect on the Hb levels. However, it is also possible PFAS detected at a higher concentration may due to its binding to higher levels of Hb. Further studies are needed to investigate the effects of PFOA/PFOS isomers on RBCs in humans.

【 授权许可】

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