Soluble Complement Component 1q Receptor 1 (sCD93) Is Associated with Graft Function in Kidney Transplant Recipients

Biomolecules

Alina Będkowska-Prokop¹  Ewa Ignacak¹  Barbara Maziarz²  Beata Kuśnierz-Cabala²  Paulina Dumnicka³  Piotr Ceranowicz⁴  Agnieszka Gala-Błądzińska⁵  Małgorzata Kielar⁶ 

[1] Chair and Department of Nephrology, Faculty of Medicine, Jagiellonian University Medical College, 30-688 Kraków, Poland;Chair of Clinical Biochemistry, Department of Diagnostics, Faculty of Medicine, Jagiellonian University Medical College, 31-066 Kraków, Poland;Department of Medical Diagnostics, Faculty of Pharmacy, Jagiellonian University Medical College, 30-688 Kraków, Poland;Department of Physiology, Faculty of Medicine, Jagiellonian University Medical College, 31-531 Kraków, Poland;Institute of Medical Sciences, Medical College of Rzeszów University, 35-310 Rzeszów, Poland;Medical Diagnostic Laboratory with a Bacteriology Laboratory, St. Louis Regional Children’s Hospital, 31-503 Kraków, Poland;

关键词: kidney allograft;    glomerular filtration rate;    soluble cluster of differentiation 93;    inflammation;    albuminuria;   

DOI  :  10.3390/biom11111623

来源: DOAJ

【 摘 要 】

Cluster of differentiation 93 (CD93), also known as complement component 1q receptor 1 is a transmembrane glycoprotein expressed in endothelial and hematopoietic cells and associated with phagocytosis, cell adhesion, angiogenesis and inflammation. The extracellular part, soluble CD93 (sCD93), is released to body fluids in inflammation. Data on sCD93 in kidney diseases are limited. Our aim was to evaluate serum sCD93 in long-term kidney transplant recipients as a marker of inflammation and endothelial dysfunction that may be potentially useful in early recognition of graft dysfunction. Seventy-eight adult patients with functioning kidney graft and stable clinical state were examined at least one year after kidney transplantation. Serum sCD93 was measured by enzyme immunosorbent assay. Estimated glomerular filtration rate (eGFR) and albuminuria or proteinuria were assessed at baseline and over one-year follow-up. Increased sCD93 was associated with lower baseline eGFR independently of the confounders. Moreover, sCD93 was negatively associated with eGFR during one-year follow-up in simple analysis; however, this was not confirmed after adjustment for confounders. Baseline sCD93 was positively associated with baseline albuminuria and with increased proteinuria during the follow-up. Serum sCD93 was not correlated with other studied inflammatory markers (interleukin 6, C-reactive protein, procalcitonin and C3 and C4 complement components). To the best of our knowledge, this is the first report regarding the concentrations of sCD93 in kidney transplant recipients and one of the first reports showing the inverse association between sCD93 and renal function. Serum sCD93 should be further evaluated as a diagnostic and prognostic marker in renal transplantation.

【 授权许可】

Unknown