Intermittent Theta Burst Stimulation vs. High-Frequency Repetitive Transcranial Magnetic Stimulation in the Treatment of Methamphetamine Patients

Frontiers in Psychiatry

Da Dong²  Zhiyong Zhao³  Qingming Liu⁴  Huimeng Sun⁵  Ying Shen⁵  Yitian Hu⁵  Qiongyao Wang⁵ 

[1] Instrument Science, Zhejiang University, Hangzhou, China;Center for Brain, Mind and Education, Shaoxing University, Shaoxing, China;;Key Laboratory for Biomedical Engineering of Ministry of Education, Department of Biomedical Engineering, College of Biomedical Engineering &School of Psychology, Nanjing Normal University, Nanjing, China;School of Teacher Education, Shaoxing University, Shaoxing, China;

关键词: methamphetamine use disorder;    iTBS;    rTMS;    substance abuse;    addiction;   

DOI  :  10.3389/fpsyt.2022.842947

来源: DOAJ

【 摘 要 】

Background and AimsIn this brief report, we compare the effectiveness and safety of intermittent theta burst stimulation (iTBS) and conventional 10 Hz repetitive transcranial magnetic stimulation (rTMS) in patients with methamphetamine use disorder (MAUD). Our study suggests that iTBS would also reduce drug craving in patients with MAUD just as the 10 Hz; thus, there may be no difference in treatment effects between these two methods.MethodsIn total twenty male methamphetamine (MA) addicts were randomly assigned to iTBS (n = 10) or 10 Hz (n = 10) groups for 12 treatments. Cue-evoked cravings, anxiety, depression, and withdrawal symptoms were measured at baseline before the first treatment, and post-tests after days 10, 15, and 20.ResultsThe results showed that iTBS and 10 Hz treatment had similar effectiveness in reducing cue-induced craving in male addicts for MA. Both 10 Hz and iTBS improved withdrawal symptoms of patients with MAUD.ConclusionsIntermittent theta burst stimulation may be similar in effectiveness as 10 Hz in treating patients with MAUD. The clinical usefulness of rTMS could be improved substantially because of the increase in its capacity, cost, and accessibility. Importantly, the effectiveness of rTMS in the treatment of patients with MAUD is not yet proven, and should be tested in the large double-blind sham-controlled studies.

【 授权许可】

Unknown