Understanding the Pathophysiology of Exosomes in Schistosomiasis: A New Direction for Disease Control and Prevention

Frontiers in Immunology

Yue Yuan¹  Min Chen¹  Qian Chen¹  Jianping Zhao²  Bixiang Zhang²  Xiaoping Chen²  Huifang Liang²  Xin Long² 

[1] Division of Gastroenterology, Department of Internal Medicine at Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology (HUST), Wuhan, China;Hepatic Surgery Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology (HUST), Wuhan, China;

关键词: schistosomiasis;    exosome;    liver fibrosis;    diagnosis;    macrophage polarization;    treatment;   

DOI  :  10.3389/fimmu.2021.634138

来源: DOAJ

【 摘 要 】

Schistosomiasis is a parasitic disease endemic to freshwater areas of Southeast Asia, Africa, and South America that is capable of causing serious damage to the internal organs. Recent studies have linked exosomes to the progression of schistosomiasis. These structures are important mediators for intercellular communication, assist cells to exchange proteins, lipids, and genetic material and have been shown to play critical roles during host–parasite interactions. This review aims to discuss the pathophysiology of exosomes in schistosomiasis and their roles in regulating the host immune response. Understanding how exosomes are involved in the pathogenesis of schistosomiasis may provide new perspectives in diagnosing and treating this neglected disease.

【 授权许可】

Unknown