Immunological Considerations in In Utero Hematopoetic Stem Cell Transplantation (IUHCT)

Frontiers in Pharmacology

Alan eFlake¹  Marie eCsete²  Andrea Ivonne Loewendorf³ 

[1] The Children's Hospital of Philadelphia;The Huntington Medical Research Institutes;UCLA, David Geffen School of Medicine;

关键词: Central Tolerance;    regulatory T cells (T-Regs);    In utero hematopoetic stem cell transplantation;    fetal alloresponse;    maternal alloresponse;   

DOI  :  10.3389/fphar.2014.00282

来源: DOAJ

【 摘 要 】

In utero hematopoetic Stem cell transplantation (IUHCT) is an attractive approach and a potentially curative surgery for several congenical hematopoetic diseases. In practice, this application has succeeded only in the context of Severe Combined Immunodeficiency Disorders. Here, we review potential immunological hurdles for the long-term establishment of chimerism and discuss relevant models and findings from both postnatal hematopoetic stem cell transplantation and IUHCT.

【 授权许可】

Unknown