Vitamin K and Kidney Transplantation

Nutrients

Giovanni Tripepi¹  Sandro Giannini²  Andrea Aghi²  Stefania Sella²  Roberto Vettor³  AngelaM. Cheung⁴  ThomasL. Nickolas⁵  Marina Foramitti⁶  Martina Zaninotto⁷  Mario Plebani⁷  Pieter Evenepoel⁸  Maria Fusaro⁹  Giorgio Iervasi⁹  Maurizio Gallieni^1,10  Laura Cosmai^1,10  Maura Ravera^1,11 

[1] CNR-IFC, Clinical Epidemiology of Renal Diseases and Hypertension, Ospedali Riuniti, 89124 Reggio Calabria, Italy;Department of Medicine, Clinica Medica 1, University of Padua, 35128 Padova, PD, Italy;Department of Medicine, University of Padova, 35128 Padova, Italy;Department of Medicine, University of Toronto, Toronto, ON M5S, Canada;Division of Nephrology, Department of Medicine, Columbia University, New York City, NY 10032, USA;Divisione di Nefrologia e Dialisi, Renal Department, ASST-Cremona, Largo Priori 1, 26100 Cremona, Italy;Laboratory Medicine Unit, Department of Medicine, University of Padua, 35128 Padova, Italy;Laboratory of Nephrology, Department of Immunology and Microbiology, B-3000 Leuven, Belgium;National Research Council (CNR), Institute of Clinical Physiology (IFC), 56124 Pisa, Italy;Nephrology Unit, ASST Fatebenefratelli Sacco, 20157 Milano, Italy;Policlinico San Martino, 16132 Genova, Italy;

关键词: kidney;    transplant;    phylloquinone;    menaquinone;    vitamin K;    osteoporosis;   

DOI  :  10.3390/nu12092717

来源: DOAJ

【 摘 要 】

The assessment of the vitamin K status and its effects on clinical outcomes in kidney transplantation (KT) patients has sparked interest, but it is still largely unfulfilled. In part, this is due to difficulties in laboratory measurements of vitamin K, especially K2 vitamers. Vitamin K status is currently best assessed by measuring undercarboxylated vitamin-K-dependent proteins. The relative contribution of vitamin K1 and K2 to the health status of the general population and CKD (chronic kidney disease) patients, including KT patients, is also poorly studied. Through a complete and first review of the existing literature, we summarize the current knowledge of vitamin K pathophysiology and its potential role in preventing KT complications and improving organ survival. A specific focus is placed on cardiovascular complications, bone fractures, and the relationship between vitamin K and cancer. Vitamin K deficiency could determine adverse outcomes, and KT patients should be better studied for vitamin K assessment and modalities of effective therapeutic approaches.

【 授权许可】

Unknown