The Microbiome of Prostate Fluid Is Associated With Prostate Cancer

Frontiers in Microbiology

Xiaowei Ma¹  Min Li¹  Shaowei Xie²  Chenfei Chi³  Xiaoguang Shao³  Baijun Dong³  Wei Xue³  Liancheng Fan³ 

[1] Department of Clinical Laboratory, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China;Department of Ultrasound in Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China;Department of Urology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China;

关键词: prostate cancer;    prostatic fluid;    microbiome;    cancer;    prostate;   

DOI  :  10.3389/fmicb.2019.01664

来源: DOAJ

【 摘 要 】

ObjectivesTo explore the microbiome of the prostatic fluid in high prostate-specific antigen (PSA) patients.Patients and MethodsThe microbiome profiles of prostatic fluid samples from 32 prostate cancer (PCa) patients and 27 non-PCa people were assessed. Microbiome analysis was assessed by massive 16S ribosomal RNA gene sequencing.ResultsCompared with the NCA group, the microbial diversity was lower in the CA group. There were no specific microbial species in the CA group or NCA group. However, many species, such as those in the genera Alkaliphilus, Enterobacter, Lactococcus, Cronobacter, Carnobacterium, and Streptococcus, showed a significant difference between the CA group and NCA group.ConclusionThe prostate contains reduced bacteria, suggesting a possible pathophysiological correlation between the composition of the microbiome and PCa. Meanwhile, this study uncovered that the microbiome may be beneficial in maintaining the stability of the microenvironment of the prostate and provides interesting perspectives for the identification of novel biomarkers in high-PSA patients.

【 授权许可】

Unknown