Strategies Developed by Toxoplasma gondii to Survive in the Host

Frontiers in Microbiology

Faustina Pappoe¹  Li Yu²  Jilong Shen²  Wanbo Zhu³  Jingyang Li⁴ 

[1] Department of Microbiology and Immunology, School of Medical Sciences, University of Cape Coast, Cape Coast, Ghana;Department of Microbiology and Parasitology, Anhui Provincial Laboratory of Microbiology and Parasitology, Anhui Key Laboratory of Zoonoses, Anhui Medical University, Hefei, China;Graduate School of Affiliated Anhui Provincial Hospital, Anhui Medical University, Hefei, China;The Clinical Laboratory of the Third People’s Hospital of Heifei, Hefei, China;

关键词: Toxoplasma;    intracellular parasites;    cell invasion;    immune evasion;    autophagy;   

DOI  :  10.3389/fmicb.2019.00899

来源: DOAJ

【 摘 要 】

One of the most successful intracellular parasites, Toxoplasma gondii has developed several strategies to avoid destruction by the host. These include approaches such as rapid and efficient cell invasion to avoid phagocytic engulfment, negative regulation of the canonical CD40-CD40L-mediated autophagy pathway, impairment of the noncanonical IFN-γ-dependent autophagy pathway, and modulation of host cell survival and death to obtain lifelong parasite survival. Different virulent strains have even evolved different ways to cope with and evade destruction by the host. This review aims to illustrate every aspect of the game between the host and Toxoplasma during the process of infection. A better understanding of all aspects of the battle between Toxoplasma and its hosts will be useful for the development of better strategies and drugs to control the parasite.

【 授权许可】

Unknown