Human Milk Adiponectin and Leptin and Infant Body Composition over the First 12 Months of Lactation

Nutrients

Alethea Rea¹  LeighC. Ward²  Zoya Gridneva³  ChingTat Lai³  PeterE. Hartmann³  Sambavi Kugananthan³  DonnaT. Geddes³  Kevin Murray⁴ 

[1] Centre for Applied Statistics, The University of Western Australia, Crawley, Perth, WA 6009, Australia;School of Chemistry and Molecular Biosciences, The University of Queensland, St. Lucia, Brisbane, QLD 4072, Australia;School of Molecular Sciences, M310, The University of Western Australia, Crawley, Perth, WA 6009, Australia;School of Population and Global Health, The University of Western Australia, Crawley, Perth, WA 6009, Australia;

关键词: adipokines;    adiponectin;    leptin;    breastfeeding;    infant;    body composition;    bioelectrical impedance spectroscopy;    ultrasound skinfolds;    human milk;    lactation;   

DOI  :  10.3390/nu10081125

来源: DOAJ

【 摘 要 】

Human milk (HM) adipokines may influence infant feeding patterns, appetite regulation, and body composition (BC). The associations between concentrations/calculated daily intakes (CDI) of HM adipokines in the first 12 months postpartum and maternal/term infant BC, and infant breastfeeding parameters were investigated. BC of breastfeeding dyads (n = 20) was measured at 2, 5, 9, and/or 12 months postpartum with ultrasound skinfolds (infants) and bioimpedance spectroscopy (infants/mothers). 24-h milk intake and feeding frequency were measured along with whole milk adiponectin and skim and whole milk leptin (SML and WML) and CDI were calculated. Statistical analysis used linear regression/mixed effects models; results were adjusted for multiple comparisons. Adipokine concentrations did not associate with infant BC. Higher CDI of adiponectin were associated with lower infant fat-free mass (FFM; p = 0.005) and FFM index (FFMI; p = 0.009) and higher fat mass (FM; p < 0.001), FM index (FMI; p < 0.001), and %FM (p < 0.001). Higher CDI of SML were associated with higher infant FM (p < 0.001), FMI (p < 0.001), and %FM (p = 0.002). At 12 months, higher CDI of WML were associated with larger increases in infant adiposity (2–12 month: FM, p = 0.0006; %FM, p = 0.0004); higher CDI of SML were associated with a larger decrease in FFMI (5–12 months: p = 0.0004). Intakes of HM adipokines differentially influence development of infant BC in the first year of life, which is a critical window of infant programming and may potentially influence risk of later disease via modulation of BC.

【 授权许可】

Unknown