期刊论文详细信息
Frontiers in Chemistry | |
An Efficient Approach to Aromatic Aminomethylation Using Dichloromethane as Methylene Source | |
Carmine Ostacolo1  Isabel M. Gomez Monterrey1  Alessia Bertamino2  Vincenzo Vestuto2  Giacomo Pepe2  Veronica Di Sarno2  Fabrizio Merciai2  Tania Ciaglia2  Simona Musella3  Pietro Campiglia3  | |
[1] Department of Pharmacy, University of Naples “Federico II”, Naples, Italy;Department of Pharmacy, University of Salerno, Fisciano, Italy;Fondazione EBRIS, Salerno, Italy; | |
关键词: aminomethylation; ultrasound assisted; dichloromethane; indole N-1 selectivity; aza-heterocyclic compounds; | |
DOI : 10.3389/fchem.2019.00568 | |
来源: DOAJ |
【 摘 要 】
Ultrasound-promoted N-aminomethylation of indoles can be achieved in basic medium using sodium hydride and dichloromethane (DCM) as C1 donor source. This innovative amino methylation protocol results in good to excellent yields of multifunctional indole derivatives. The procedure is also applicable to other aza-heterocyclic compounds and, interestingly, affords direct access to aminomethyl-substituted aryl alcohols.
【 授权许可】
Unknown