Prospective Pharmacological Potential of Resveratrol in Delaying Kidney Aging

International Journal of Molecular Sciences

Mithila Farjana¹  Md Jamal Uddin¹  Md. Abdul Hannan¹  Akhi Moni¹  Khandkar Shaharina Hossain¹  Hunjoo Ha² 

[1]ABEx Bio-Research Center, East Azampur, Dhaka 1230, Bangladesh

[2]Graduate School of Pharmaceutical Sciences, College of Pharmacy, Ewha Womans University, Seoul 120-750, Korea

关键词: antioxidant;    anti-aging;    AKI;    CKD;    kidney aging;    resveratrol;   

DOI  :  10.3390/ijms22158258

来源: DOAJ

【 摘 要 】

Aging is an unavoidable part of life. The more aged we become, the more susceptible we become to various complications and damages to the vital organs, including the kidneys. The existing drugs for kidney diseases are mostly of synthetic origins; thus, natural compounds with minimal side-effects have attracted growing interest from the scientific community and pharmaceutical companies. A literature search was carried out to collect published research information on the effects of resveratrol on kidney aging. Recently, resveratrol has emerged as a potential anti-aging agent. This versatile polyphenol exerts its anti-aging effects by intervening in various pathologies and multi-signaling systems, including sirtuin type 1, AMP-activated protein kinase, and nuclear factor-κB. Researchers are trying to figure out the detailed mechanisms and possible resveratrol-mediated interventions in divergent pathways at the molecular level. This review highlights (i) the causative factors implicated in kidney aging and the therapeutic aspects of resveratrol, and (ii) the effectiveness of resveratrol in delaying the aging process of the kidney while minimizing all possible side effects.

【 授权许可】

Unknown