Serotonin Signals Overcome Loser Mentality in Drosophila

iScience

Yan Zhu¹  Yin Peng Zhan²  Yan Tong Yang³  Shao Wei Hu⁴  Yuanjie Sun⁴ 

[1] Sino-Danish Center for Education and Research, Beijing 100190, China;Sino-Danish College, University of Chinese Academy of Sciences, Beijing, China;University of Chinese Academy of Sciences, Beijing 100049, China;State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, 15 Datun Road, Beijing 100101, China;

关键词: Behavioral Neuroscience;    Molecular Neuroscience;    Cellular Neuroscience;   

DOI  :  

来源: DOAJ

【 摘 要 】

Summary: Traumatic experiences generate stressful neurological effects in the exposed persons and animals. Previous studies have demonstrated that in many species, including Drosophila, the defeated animal has a higher probability of losing subsequent fights. However, the neural basis of this “loser effect” is largely unknown. We herein report that elevated serotonin (5-HT) signaling helps a loser to overcome suppressive neurological states. Coerced activation of 5-HT neurons increases aggression in males and promotes losers to both vigorously re-engage in fights and even defeat the previous winners and regain mating motivation. P1 neurons act upstream and 5-HT1B neurons in the ellipsoid body act downstream of 5-HT neurons to arouse losers. Our results demonstrate an ancient neural mechanism of regulating depressive behavioral states after distressing events.

【 授权许可】

Unknown