Mannose-binding Lectin Mediated Complement Pathway in Autoimmune Neurological Disorders

Iranian Journal of Allergy, Asthma and Immunology

Nastaran Dastravan¹  Mehrdad Farrokhi²  Keyvan Ghadimi³  Mehrnoosh Dabirzadeh³  Zahra Saadatpour⁴  Ali Rezaei⁵  Masoud Etemadifar⁶ 

[1] Department of Biology, Faculty of Sciences, University of Isfahan, Isfahan, Iran;Department of Immunology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran;Department of Neurology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran;Department of Radiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran;Department of Radiology, School of Medicine, Najafabad Branch, Islamic Azad University, Isfahan, Iran;Multiple Sclerosis and Neuroimmunology Research Center, Isfahan, Iran;

关键词: Autoimmunity;    Complement system proteins;    Guillain-Barre syndrome;    Mannose-binding lectin;    Multiple sclerosis;    Myasthenia gravis;   

DOI  :  

来源: DOAJ

【 摘 要 】

Multiple sclerosis (MS) is a complex, demyelinating disease of the central nervous system (CNS) with variable phenotypic presentations, while Guillain-Barre Syndrome (GBS) is the prototypic acute inflammatory disorder that affects the peripheral nervous system. Myasthenia gravis (MG) is a T cell dependent and antibody mediated autoimmune disease. Although it has been shown that complement plays a critical role in the pathogenesis of MS, GBS, and MG, the role of mannose-binding lectin (MBL) as a biomarker of immunopathogensis of these diseases and also its association with the severity of them have been poorly investigated. Therefore, in this study we aimed to measure plasma levels of MBL in patients with MS, GBS, and MG. In a case-control study, plasma was obtained from healthy controls (n=100) and also patients with MS (n=120), GBS (n=30), and MG (n=30). Plasma level measurement of MBL was performed using enzyme-linked immunosorbent assay (ELISA). The mean serum level of MBL was significantly different between groups of patients and healthy controls (p<0.001). We also found a positive correlation between plasma levels of MBL and severity scores of MS, MG, and GBS patients including: expanded disability status scale (EDSS) (r=+0.60 and p=<0.001), quantitative myasthenia gravis score (QMGS) (r=+0.56 and p=0.01), and GBS disability scale (GDS) (r=+0.37 and p=0.04). Taken together, our findings suggest that complement activation mediated by MBL contributes to the pathogenesis and also severity of MS, MG, and GBS. However, because the lectin pathway can be involved in several phases of the immune response, further evidence will be required to elucidate the underlying mechanism.

【 授权许可】

Unknown