Cranial neural tube defect after trimethoprim exposure

BMC Research Notes

Azlina Ahmad-Annuar¹  Meow-Keong Thong²  Anis Shuhada Mohd-Salleh³  Siti Waheeda Mohd-Zin³  Bee-Hui Lim³  Noraishah Mydin Abdul-Aziz³  Nor Linda Abdullah³  Zakaria Nurul Aiezzah³  Renuka Gunasekaran³  Pramila Maniam³  Noreena Nordin⁴  Zamri Chik⁵  Zaliha Omar⁶  Julia Patrick Engkasan⁶  Dharmendra Ganesan⁷ 

[1] Department of Biomedical Science, Faculty of Medicine, University of Malaya;Department of Paediatrics, Faculty of Medicine, University of Malaya;Department of Parasitology, Faculty of Medicine, University of Malaya;Department of Pharmacology, Faculty of Medicine, University of Malaya Bioequivalence and Testing Centre (UBAT), University of Malaya;Department of Pharmacology, Faculty of Medicine, University of Malaya;Department of Rehabilitation Medicine, Faculty of Medicine, University of Malaya;Department of Surgery, Faculty of Medicine, University of Malaya;

关键词: Neural tube defects;    Trimethoprim;    Folic acid antagonist;    Acne;    Primary neurulation;    Malaysia;   

DOI  :  10.1186/s13104-018-3593-1

来源: DOAJ

【 摘 要 】

Abstract Objectives The Neural Tube Defects Research Group of University of Malaya was approached to analyze a tablet named TELSE, which may have resulted in a baby born with central nervous system malformation at the University of Malaya Medical Centre. In this animal experimental study, we investigated the content of TELSE and exposure of its contents that resulted in failure of primary neurulation. Results Liquid Chromatography Tandem Mass spectrophotometry analysis of the TELSE tablet confirmed the presence of trimethoprim as the active compound. The TELSE tablet-treated females produced significant numbers of embryos with exencephaly (n = 8, 36.4%, *P < 0.0001), in all litters. The TELSE tablet-treated females subsequently given folic acid did not result in pregnancies despite there being evidence of possible resorption. Furthermore, after multiple rounds of mating which did not yield viable pregnancies, eventually, 2 embryos with exencephaly were harvested in a litter of 6 at 0.05% w/v pure trimethoprim once. The use of trimethoprim, a folic acid antagonist, peri-conceptionally increased the risk of exencephaly in the mouse.

【 授权许可】

Unknown