Dose-Dependent Blood-Feeding Activity and Ovarian Alterations to PM2.5 in Aedes aegypti

Insects

Chaisith Sivakorn¹  Thipruethai Phanitchat²  Thammanitchpol Denpetkul³  Sumate Ampawong⁴  Mongkhon Sompornrattanaphan⁵  Artit Yawootti⁶  Napid Wadmanee⁷ 

[1] Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand;Department of Medical Entomology, Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand;Department of Social and Environmental Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand;Department of Tropical Pathology, Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand;Division of Allergy and Clinical Immunology, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand;Faculty of Engineering, Rajamangala University of Technology LANNA, Chiang Mai 50300, Thailand;Hospital for Tropical Disease, Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand;

关键词: Aedes aegypti;    PM_2.5;    blood-feeding;    pollution;    arbovirus;   

DOI  :  10.3390/insects12100948

来源: DOAJ

【 摘 要 】

High levels of fine particulate matter (PM_2.5) air pollution are a concern for human health. Several studies have examined the effects of air pollution on human and animal health. However, there is a lack of knowledge about its effects on arbovirus vectors. Thus, we investigated whether PM_2.5 concentration alters the blood-feeding activity of Ae. aegypti mosquitoes. We investigated the effect on the females’ propensity to blood feed at eight concentrations of PM_2.5 ranging from 100 to 1000 μg/m³. Correlation analysis showed blood-feeding activity had a significant strong negative correlation with concentration of PM_2.5 (r_p = −0.85; p ≤ 0.00001). Exploratory linear and non-linear models showed an exponential decay relationship was the best fitting model (corrected Akaike’s information criterion, 193.0; Akaike’s weight, 0.766; adjusted R², 0.780). Ultrastructural study demonstrated PM_2.5 did not obstruct the respiratory system, but some fine particles were present on the antenna and abdominal body parts. Ovaries showed a dose–response relationship between PM_2.5 level and vacuolated degeneration. In conclusion, the blood-feeding behavior of Ae. aegypti females may have an exponential decay relationship with PM_2.5 level, and their ovaries may demonstrate dose-dependent degeneration. These findings may be important in understanding the vector’s biology and disease transmission in settings with high PM_2.5 levels. These results are important to understand blood-feeding and feeding pattern of mosquitoes during PM_2.5 pollution, which is important for disease transmission and vector control.

【 授权许可】

Unknown