期刊论文详细信息
Natural Products and Bioprospecting
Anti-oral Microbial Flavanes from Broussonetia papyrifera Under the Guidance of Bioassay
Meng-Hong Yan1  Ji-Jun Chen1  Chang-An Geng1  Xue-Mei Zhang1 
[1] State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences;
关键词: Bropapyriferol;    Broussonetia papyrifera;    Anti-oral microbial activity;   
DOI  :  10.1007/s13659-019-0197-y
来源: DOAJ
【 摘 要 】

Abstract A new flavane, bropapyriferol (1), and eleven known ones were isolated from the EtOAc part of Broussonetia papyrifera under the guidance of bioassay. The structure of compound 1 was determined by extensive 1D and 2D NMR, [α]D spectroscopic data and quantum computation. Daphnegiravan F (2) and 5,7,3′,4′-tetrahydroxy-3-methoxy-8,5′-diprenylflavone (3) showed significantly anti-oral microbial activity against five Gram-positive strains and three Gram-negative strains in vitro. Especially, compound 3 was more potent in suppressing Actinomyces naeslundii and Porphyromonas gingivalis (MIC = 1.95 ppm) than the positive control, triclosan. Graphical Abstract

【 授权许可】

Unknown   

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