Soluble (pro)renin receptor in elderly chronic heart failure patients

Frontiers in Bioscience-Landmark

Harald Heidecke¹  Burkert Pieske²  Elvis Tahirovic²  Jovan Veskovic²  Hans-Dirk Dungen²  Sara Radenovic²  Vuk Savkovic³  Marija Zdravkovic³  Danilo Obradovic⁴  Petra Buttner⁴  Kai Schulze-Forster⁵  Ralf Dechend⁶  Dominik Muller⁶  Andreas Busjahn⁷  Goran Loncar⁸  Simin Li⁹  Haluo Li⁹ 

[1] CellTrend GmbH, Im Biotechnologiepark, Luckenwalde 14943;Department of Cardiology Campus Virchow, Charite Universitatsmedizin Berlin, Berlin 13353;Department of Cardiology, University Clinical Hospital “Bezanijska Kosa”, University of Belgrade, Belgrade 11000;Department of Cardiology-Internal Medicine, Heart Center Leipzig, University Leipzig, Leipzig 04289;Department of Urology, Charite Universitatsmedizin Berlin, Berlin 10117;Experimental and Clinical Research Center, Max Delbruck Center for Molecular Medicine, Berlin 13125;HealthTwiSt GmbH, Berlin, German 13125;Institute for Cardiovascular Diseases “Dedinje”, University of Belgrade, Belgrade 11040;Saxon Incubator for Clinical Translation, University Leipzig, Leipzig 04103;

关键词: chronic heart failure;    soluble (pro)renin receptor;    left ventricular ejection fraction;    left ventricular remodeling;   

DOI  :  10.2741/4880

来源: DOAJ

【 摘 要 】

Overactivation of renin-angiotensin system (RAS) is one of the main pathophysiological features in the evolution of chronic heart failure (CHF). The (pro)renin receptor ((P)RR) represents an important player in a tissue renin-angiotensin system (tissue RAS), which mediates tissue injury through fibrosis and hypertrophy of the affected organs in CHF patients. In our study we used plasma samples from 556 elderly subjects with CHF and 198 healthy participants in order to evaluate prognostic and diagnostic potential of s(P)RR in setting of CHF. The patients with CHF showed significantly higher plasma levels of s(P)RR than the healthy volunteers (p=0.0005). We observed association between higher s(P)RR plasma concentrations and lower left ventricular ejection fraction and higher degree of left ventricular dilatation on baseline echocardiography examination of the CHF patients. Elderly CHF patients with higher baseline s(P)RR plasma concentration were at same risk for death, stroke and hospitalization due to heart failure worsening at mean follow-up from forty-eight months in comparison to low s(P)RR counterparts.

【 授权许可】

Unknown