Hemophagocytic syndrome associated to hepatitis

Revista Alergia México

Oswaldo Plascencia-Tabares¹  Nery Eduardo-Solís²  Eunice Sandoval-Ramírez²  Ignacio Camacho-Meza²  Efraín Navarro-Olivos³  Francisco Ignacio Ortiz-Aldana³ 

[1] Instituto Mexicano del Seguro Social, Hospital de Especialidades Pediátrico, León, Guanajuato;Instituto Mexicano del Seguro Social, Hospital de Especialidades Pediátrico, Servicio de Alergia e Inmunología Clínica Pediátrica, León, Guanajuato;Secretaría de Salud, Instituto de Salud Pública del Estado de Guanajuato, Guanajuato;

关键词: síndrome;    hemofagocitosis;    hepatitis;    citocinas;    macrófago;   

DOI  :  10.29262/ram.v63i1.133

来源: DOAJ

【 摘 要 】

Hemophagocytic syndrome is characterized by increased proliferation and activation of antigen presenting cells (histiocytes) in bone marrow and other organs of the reticuloendothelial system as well as CD8+ T cells that threatens life of patients. The predominant clinical manifestations such as fever, cytopenia, hepatitis, coagulopathy, neurological symptoms and multiple organ failure are related to systemic inflammation. We report the case of an infant who started with jaundice, abdominal pain, vomiting and malaise, at admission, hepatomegaly, splenomegaly and biochemically with features suggestive of hepatocellular inflammation and progressive cholestasis with poor outcome, it was added persistent fever, seizures, anemia, thrombocytopenia, leukopenia, elevated ferritin and hypertriglyceridemia integrating hemophagocytic syndrome with fatal outcome despite immunosuppressive therapy.

【 授权许可】

Unknown