Endocrine Connections | |
New insights into the links between anti-diabetes drugs and gut microbiota | |
Yanting Yuan1  Ji Zhou1  Guohui Jiang1  Ruixin Hu1  Lixia Ji1  Chaolong Liu1  | |
[1] School of pharmacy, Qing Dao University, Qingdao, China; | |
关键词: gut microbiota; leaky gut; functional pancreatic β-cells; short-chain fatty acids (scfas); anti-diabetes drugs; type 2 diabetes mellitus (t2dm); | |
DOI : https://doi.org/10.1530/EC-20-0431 | |
来源: DOAJ |
【 摘 要 】
In patients with type 2 diabetes mellitus (T2DM), the intestina l flora is out of balance and accompanied by leaky gut. The flora is characterized by an incre ase in mucus-degrading bacteria and a decrease in fiber-degrading bacteria. Short-chain fatty acids (SCFAs), as the major fiber-degrading bacteria fermentation, not only amelio rate the leaky gut, but also activate GPR43 to increase the mass of functional pancreatic β-cells and exert anti-inflammation effect. At present, the gut microbiota is considered as the potential target for anti-diabetes drugs, and how to reverse the imbalance of gu t microbiota has become a therapeutic strategy for T2DM. This review briefly summarizes the drugs or compounds that have direct or potential therapeutic effects on T 2DM by modulating the gut microbiota, including biguanides, isoquinoline alkaloids, stilbene and C7N-aminocyclic alcohols.
【 授权许可】
Unknown