Investigation of Early Supplementation of Nucleotides on the Intestinal Maturation of Weaned Piglets

Animals

Paolo Bosi¹  Paolo Trevisi¹  Federico Correa¹  Diana Luise¹  Ivonne Archetti² 

[1] Department of Agricultural and Food Sciences (DISTAL), Alma Mater Studiorum-University of Bologna, Viale G. Fanin 46, 40127 Bologna, Italy;Istituto Zooprofilattico Sperimentale della Lombardia e dell’Emilia Romagna (IZSLER), “Bruno Ubertini”, Via Bianchi, 9, 25124 Brescia, Italy;

关键词: immunity;    intestinal maturation;    microbiota;    nucleotides;    piglet;    transcriptome;   

DOI  :  10.3390/ani11061489

来源: DOAJ

【 摘 要 】

Nucleotides are essential for the development of the gastrointestinal tract and immune function, but their intake with milk by piglets could be insufficient. The effect of nucleotides on growth and health was tested on 98 piglets divided into two groups: NU, orally administrated with 4 mL of a nucleotide-based product (SwineMOD^®) at 10, 15, 18, 21, 27 days, or not (CO). Blood and feces were sampled at weaning (26 d, T1), and at 38 d (T2). Per each group and time-point, eight piglets were slaughtered and jejunal Peyer’s patches (JPPs) were collected. NU increased hemoglobin content and hematocrit, but not growth. At weaning, the NU fecal microbiota was characterized by the abundance of Campylobacteraceae, more typical of the growing phase, compared to CO, with a greater abundance of Streptococcaceae. For the blood transcriptome, an initial greater inflammatory activation was seen in CO, while at T2, NU enriched gene sets related to erythropoiesis. The activation of gene groups ranging from epigenetic response to transcriptional regulation evidenced an intense proliferative activity in NU JPPs. NU supplementation did not influence the growth performance of piglets but could have expressed a positive effect on pig microbiota anticipating its maturation at weaning. This immunostimulant activity in the JPPs could moderate the inflammation in the immediate pre-weaning.

【 授权许可】

Unknown