Combined analysis of ZAP-70 and CD38 expression in sudanese patients with B-cell chronic lymphocytic leukemia

BMC Research Notes

Othman Saeed BaHashwan¹  Ameen Abdulaziz Basabaeen²  Saadia Osman Abdelrahim²  Ibrahim Khider Ibrahim²  Ebtihal Ahmed Babekir²  Nour Mahmoud Abdelateif²  Enaam Abdelrhman Abdelgader³  Eman Abbass Fadul⁴  Osama Ali Altayeb⁴  Salem Ahmed Bamusa⁵ 

[1] Department of Family Medicine, Faculty of Medicine, University of Gezira;Department of Hematology, Faculty of Medical Laboratory Sciences, Al Neelain University;Department of Pathology, Faculty of Medicine, Al Neelain University;Flow Cytometry Laboratory for Leukemia & Lymphoma Diagnosis;Ministry of Health & Population;

关键词: B-CLL;    ZAP-70;    CD38;    Combined;    Rai;    Binet;   

DOI  :  10.1186/s13104-019-4319-8

来源: DOAJ

【 摘 要 】

Abstract Objective To investigate the ZAP-70 and CD38 expressions and their combined expressions in Sudanese B-CLL patients and their relationships with clinical and hematological characteristics as well as the disease staging at presentation. Results In the present cross-sectional descriptive study, analysis of ZAP-70 expression showed that 36/110 (32.7%) patients positively expressed ZAP-70 and insignificant higher presentation in intermediate and at advanced stages as well as no correlation was seen with hematological parameters and clinical features compared with negatively ZAP-70, on the other hand, 41/110 (37.3%) were CD38+ and no significant correlation was shown with the stage at presentation, clinical characteristics (except Splenomegaly, P = 0.02) and hematological parameters. However, in combined expressions of both ZAP-70 and CD38 together, 20/110 (18.2%) were concordantly ZAP-70+/CD38+, 53/110 (48.2%) concordantly ZAP-70−/CD38− and 37/110 (33.6%) either ZAP-70+ or CD38+, and these three groups showed insignificant correlation with clinical (except Splenomegaly, P = 0.03) and hematological parameters, and the stage at presentation. Our data showed the combined analysis of these two markers, lead to classify our patients into three subgroups (either concordant positive, negative or discordant expressions) with statistically insignificant correlation with clinical presentation (except Splenomegaly), hematological parameters and stage at presentation of B-CLL patients.

【 授权许可】

Unknown