Immunothrombosis in COVID-19: Implications of Neutrophil Extracellular Traps

Biomolecules

Manuel Castillejos-López¹  Samuel Sevilla-Fuentes²  LauraM. Hernández-Regino³  CarlosA. García-Ávila³  Alejandro Hanono⁴  Angel Camarena⁵  Armida Juárez-Cisneros⁵  Brandon Bautista-Becerril⁵  Arnoldo Aquino-Gálvez⁶  Al Flores-Bustamante⁷  Rebeca Campi-Caballero⁸  Julieta González-Flores⁸ 

[1] Departamento de Epidemiología Hospitalaria e Infectología, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Mexico City 14080, Mexico;Departamento de Infectología, Hospital General de México Eduardo Liceaga, Mexico City 06720, Mexico;Escuela Nacional de Ciencias Biológicas, Programa de Posgrado, Instituto Politécnico Nacional, Mexico City 11340, Mexico;Facultad de Ciencias de la Salud, Universidad Anáhuac México Norte, Mexico City 52786, Mexico;Laboratorio HLA, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Mexico City 14080, Mexico;Laboratorio de Biología Molecular, Departamento de Fibrosis Pulmonar, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Mexico City 14080, Mexico;Laboratorio de Farmacología, Instituto Nacional de Pediatría, Mexico City 04530, Mexico;Programa MEDICI, Carrera Médico Cirujano, FES Iztacala, Universidad Nacional Autónoma de México, Mexico City 54090, Mexico;

关键词: immunothrombosis;    COVID-19;    neutrophil extracellular traps;    CID;    SARS-CoV-2;   

DOI  :  10.3390/biom11050694

来源: DOAJ

【 摘 要 】

SARS-CoV-2 is a member of the family of coronaviruses associated with severe outbreaks of respiratory diseases in recent decades and is the causative agent of the COVID-19 pandemic. The recognition by and activation of the innate immune response recruits neutrophils, which, through their different mechanisms of action, form extracellular neutrophil traps, playing a role in infection control and trapping viral, bacterial, and fungal etiological agents. However, in patients with COVID-19, activation at the vascular level, combined with other cells and inflammatory mediators, leads to thrombotic events and disseminated intravascular coagulation, thus leading to a series of clinical manifestations in cerebrovascular, cardiac, pulmonary, and kidney disease while promoting severe disease and mortality. Previous studies of hospitalized patients with COVID-19 have shown that elevated levels of markers specific for NETs, such as free DNA, MPO, and H3Cit, are strongly associated with the total neutrophil count; with acute phase reactants that include CRP, D-dimer, lactate dehydrogenase, and interleukin secretion; and with an increased risk of severe COVID-19. This study analyzed the interactions between NETs and the activation pathways involved in immunothrombotic processes in patients with COVID-19.

【 授权许可】

Unknown