Reemergence of Intravenous Drug Use as Risk Factor for Candidemia, Massachusetts, USA

Emerging Infectious Diseases

关键词: candidemia;    candidiasis;    Candida albicans;    intravenous substance abuse;    heroin;    endocarditis;   

DOI  :  10.3201/eid2404.171807

来源: DOAJ

【 摘 要 】

The epidemic of illicit intravenous drug use (IVDU) in the United States has been accompanied by a surge in drug overdose deaths and infectious sequelae. Candida albicans infections were associated with injection of contaminated impure brown heroin in the 1970s–1990s; however, candidiasis accompanying IVDU became considerably rarer as the purity of the heroin supply increased. We reviewed cases of candidemia occurring over a recent 7-year period in persons >14 years of age at a tertiary care hospital in central Massachusetts. Of the 198 patients with candidemia, 24 cases occurred in patients with a history of IVDU. Compared with non-IVDU patients, those with a history of IVDU were more likely to have non-albicans Candida, be co-infected with hepatitis C, and have end-organ involvement, including endocarditis and osteomyelitis. Thus, IVDU appears to be reemerging as a risk factor for invasive candidiasis.

【 授权许可】

Unknown