Rupture Risk Assessment for Mirror Aneurysms with Different Outcomes in the Same Patient

Frontiers in Neurology

Linkai Jing¹  Yisen Zhang²  Zhongbin Tian²  Ying Zhang²  Jian Liu²  Xinjian Yang² 

[1] Department of Neurosurgery, Beijing Tsinghua Changgung Hospital, Medical Center, Tsinghua University, Beijing, 102218, China.;Departments of Interventional Neuroradiology, Beijing Neurosurgical Institute and Beijing Tiantan Hospital, Capital Medical University, Beijing, China;Medical Center, Tsinghua University, Beijing, 100084, China.;

关键词: Hemodynamics;    computational fluid dynamics;    Morphologic;    Rupture.;    intracranial mirror aneurysms;   

DOI  :  10.3389/fneur.2016.00219

来源: DOAJ

【 摘 要 】

Background: The purpose of this research was to analyze the effect of morphologic and hemodynamic characteristics on mirror aneurysms in which one ruptured and the other did not, within the same patient, and to identify reliable predictors of rupture.Methods: We performed three-dimensional angiographic imaging in 56 patients with intracranial mirror aneurysms for computational fluid dynamic studies from January 2009 to December 2015. The ruptured aneurysm simulations were conducted with geometry obtained after rupture. The significance of morphologic and hemodynamic parameters with respect to rupture was analyzed. Multivariate logistic regression analysis was applied to significant parameters to identify independent discriminators.Results: Three morphologic factors (aneurysm size, aspect ratio, and size ratio) and two hemodynamic factors (time-averaged mean wall shear stress WSS and low WSS area LSA) were statistically associated with aneurysm rupture (p<0.05). On multivariate logistic regression, a larger size (OR 2.572, p=0.001) and lower WSS (OR 0.609, p=0.045) were independent significant factors for rupture.Conclusions: Larger aneurysm size and lower WSS were independently associated with the rupture status of aneurysms. These findings need to be confirmed by large multicenter and multipopulation studies.

【 授权许可】

Unknown