Pyrazoline Hybrids as Promising Anticancer Agents: An Up-to-Date Overview

International Journal of Molecular Sciences

Dimitris Matiadis¹  Marina Sagnou¹ 

[1] National Center for Scientific Research “Demokritos”, Institute of Biosciences & Applications, 153 10 Athens, Greece;

关键词: pyrazolines;    hybrid compounds;    conjugates;    anticancer;    antitumor;    cytotoxicity;   

DOI  :  10.3390/ijms21155507

来源: DOAJ

【 摘 要 】

Pyrazolines are five-membered heterocycles possessing two adjacent nitrogens. They have attracted significant attention from organic and medicinal chemists due to their potent biological activities and the numerous possibilities for structural diversification. In the last decade, they have been intensively studied as targets for potential anticancer therapeutics, producing a steady yearly rise in the number of published research articles. Many pyrazoline derivatives have shown remarkable cytotoxic activities in the form of heterocyclic or non-heterocyclic based hybrids, such as with coumarins, triazoles, and steroids. The enormous amount of related literature in the last 5 years prompted us to collect all these published data from screening against cancer cell lines, or protein targets like EGFR and structure activity relationship studies. Therefore, in the present review, a comprehensive account of the compounds containing the pyrazoline nucleus will be provided. The chemical groups and the structural modifications responsible for the activity will be highlighted. Moreover, emphasis will be given on recent examples from the literature and on the work of research groups that have played a key role in the development of this field.

【 授权许可】

Unknown