期刊论文详细信息
Drug Design, Development and Therapy
A case report of toxic epidermal necrolysis associated with AZD-9291
关键词: TEN;    AZD-9291;    Osimertinib;    EGFR-TKIs;    NSCLC;   
DOI  :  
来源: DOAJ
【 摘 要 】

Jie Wang, XianYe Cheng, Yan Lu, BingRong ZhouDepartment of Dermatology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, The People’s Republic of ChinaAbstract: Epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) are a strain of small molecule inhibitors mainly used to treat the metastatic non-small cell lung cancer. Their predominant adverse effect is skin toxicity, usually manifested as acneiform rash, skin fissure, xerosis, and paronychia. Severe epidermal necrosis and exfoliation rarely occur. As one of the new generation of epidermal growth factor receptor-tyrosine kinase inhibitors, AZD-9291 is claimed to have better efficacy and fewer side effects, particularly appropriate for patients with EGFR T790M mutation. Herein we report a 51-year-old man who developed a large area of skin necrosis and was diagnosed with toxic epidermal necrolysis after AZD-9291 ingestion.Keywords: TEN, AZD-9291, osimertinib, EGFR-TKIs, NSCLC

【 授权许可】

Unknown   

  文献评价指标  
  下载次数:0次 浏览次数:0次