Canstatin induces apoptosis in gastric cancer xenograft growth in mice through the mitochondrial apoptotic pathway

Bioscience Reports

Hui‑Mian Xu¹  Peng Deng¹  Ya‑Nan Xing¹ 

[1] Department of Surgical Oncology, First Affiliated Hospital of China Medical University, Shenyang 110001, China;

关键词: canstatin;    chick chorioallantoic membrane;    gastric cancer;    mitochondrial apoptotic pathway;    survival rate;   

DOI  :  10.1042/BSR20140012

来源: DOAJ

【 摘 要 】

Canstatin, the non-collagenous domain of collagen type IV α-chains, belongs to a series of collagen-derived angiogenic inhibitors. In this study, the inhibitory effect of recombinant canstatin on tumour growth was investigated using a gastric cancer xenograft model. The volume and weight of tumours in mice treated with canstatin were lower than that in mice treated with PBS. Accordingly, the survival rate of these mice was significantly higher than that of mice bearing tumours treated with PBS. Moreover, valuable insight into the mechanisms mediated by canstatin was obtained.

【 授权许可】

Unknown