Real-Time Temperature Detection Via Quantum Dots for Photothermal Cellular Actuation

Proceedings

Jolan Wellens¹  Stijn Jooken¹  Fanglei Guo¹  Carmen Bartic¹  Wei Yu¹  Pengfei Zhang¹  Christ Glorieux¹  Olivier Deschaume¹ 

[1] Soft-Matter Physics and Biophysics Unit, Department of Physics and Astronomy, Katholieke Universiteit Leuven, 3000 Leuven, Belgium;

关键词: cell actuation;    plasmonic heating;    thermal mapping;    extracellular matrices;   

DOI  :  10.3390/proceedings2020056040

来源: DOAJ

【 摘 要 】

Plasmonic heating finds multiple applications in cell manipulation and stimulation, where heat generated by metal nanoparticles can be used to modify cell adhesion, control membrane currents, and suppress neuronal action potentials among others. Metal nanoparticles can also be easily integrated in artificial extracellular matrices to provide tunable, thermal cueing functionalities with nanometer spatial resolution. In this contribution, we present a platform enabling the combination of plasmonic heating with localized temperature sensing using quantum dots (QDs). Specifically, a functional nanocomposite material was designed with gold nanorods (AuNRs) and QDs incorporated in a cell-permissive hydrogel (e.g., collagen) as well as an optical set-up combining optical heating and temperature imaging, respectively. Specific area stimulation/readout can be realized through structured illumination using digital micromirror device (DMD) projection.

【 授权许可】

Unknown