期刊论文详细信息
Zhongliu Fangzhi Yanjiu | |
Effect of SABP, A Water-soluble Component of Salvia Miltiorrhiza, on Immune Microenvironment of Mice with Liver Cancer | |
GUO Yinglin1  HAO Liyuan1  PENG Qing1  DING Jingru1  LI Shenghao2  SHI Xinli2  | |
[1]Basic Medical College, Hebei University of Chinese Medicine, Shijiazhuang 050200, China | |
[2]Hebei Provincial Key Laboratory of Integrative Medicine for Liver & Kidney Diseases, Shijiazhuang 050091, China | |
关键词: salvia miltiorrhiza; water-soluble component; hepatocellular carcinoma; immune microenvironment; orthotopic transplantation tumor; | |
DOI : 10.3971/j.issn.1000-8578.2021.20.1405 | |
来源: DOAJ |
【 摘 要 】
Objective To investigate the effect of SABP, a water-soluble component of Salvia miltiorrhiza, on the growth of orthotopic transplantation of H22 liver cancer and the immune microenvironment of liver cancer. Methods We established a mouse model of orthotopic transplantation of H22 cell liver cancer in BALB/c mice. ELISA was used to detect the expression of PD-L1, TGF-β, IL-1β, IL-10, IL-4, IFN-γ, IL-18, IL-7, IL-2, CCL-2 and CCL-21 in the liver. We counted the organ indexes of liver, spleen and kidney. Results SABP inhibited the growth of orthotopic transplantation tumors of H22 cell liver cancer, and increased the expression levels of PD-L1, TGF-β, IL-1β and IL-10 in the microenvironment of liver cancer, as well as the liver, spleen and kidney coefficients. Conclusion SABP could inhibit the growth of orthotopic transplantation tumors of H22 cell liver cancer and promote the expression of PD-L1, TGF-β, IL-1β and IL-10 in the microenvironment of liver cancer.【 授权许可】
Unknown