Effect of SABP, A Water-soluble Component of Salvia Miltiorrhiza, on Immune Microenvironment of Mice with Liver Cancer

Zhongliu Fangzhi Yanjiu

GUO Yinglin¹  HAO Liyuan¹  PENG Qing¹  DING Jingru¹  LI Shenghao²  SHI Xinli² 

[1]Basic Medical College, Hebei University of Chinese Medicine, Shijiazhuang 050200, China

[2]Hebei Provincial Key Laboratory of Integrative Medicine for Liver & Kidney Diseases, Shijiazhuang 050091, China

关键词: salvia miltiorrhiza;    water-soluble component;    hepatocellular carcinoma;    immune microenvironment;    orthotopic transplantation tumor;   

DOI  :  10.3971/j.issn.1000-8578.2021.20.1405

来源: DOAJ

【 摘 要 】

Objective To investigate the effect of SABP, a water-soluble component of Salvia miltiorrhiza, on the growth of orthotopic transplantation of H22 liver cancer and the immune microenvironment of liver cancer. Methods We established a mouse model of orthotopic transplantation of H22 cell liver cancer in BALB/c mice. ELISA was used to detect the expression of PD-L1, TGF-β, IL-1β, IL-10, IL-4, IFN-γ, IL-18, IL-7, IL-2, CCL-2 and CCL-21 in the liver. We counted the organ indexes of liver, spleen and kidney. Results SABP inhibited the growth of orthotopic transplantation tumors of H22 cell liver cancer, and increased the expression levels of PD-L1, TGF-β, IL-1β and IL-10 in the microenvironment of liver cancer, as well as the liver, spleen and kidney coefficients. Conclusion SABP could inhibit the growth of orthotopic transplantation tumors of H22 cell liver cancer and promote the expression of PD-L1, TGF-β, IL-1β and IL-10 in the microenvironment of liver cancer.

【 授权许可】

Unknown