Incidence of Post-Operative Complications and Factors Influencing Their Occurrence in Patients with Sickle Cell Disease in a Low-Income Country: A Case Study of Cameroon

Journal of Clinical Medicine

Dominique Djomo Tamchom¹  Charlotte Eposse Ekoube²  Fleur Samantha Benghiat³  Basile Essola³  Luc Van Obbergh³  Serge Nga Nomo⁴ 

[1] Faculty of Health Sciences, University of Buea, Buea 63, Cameroon;Faculty of Medicine and Pharmaceutical Sciences, University of Douala, Douala 2701, Cameroon;Faculty of Medicine, Free University of Brussels, 1070 Brussels, Belgium;Higher Institute of Medical Technology, Yaoundé 188, Cameroon;

关键词: patient with sickle cell disease;    anaesthesia;    surgery;    post-operative complications;    incidence;   

DOI  :  10.3390/jcm11030780

来源: DOAJ

【 摘 要 】

This study aimed to analyse post-operative complications and possible factors influencing their occurrence in the management of patients with sickle cell disease in a low-income country. We prospectively collected data regarding the management of patients with sickle cell disease requiring anesthesia for surgery in 11 Cameroonian hospitals from 1 May 2019 to 30 April 2021. The data were analysed using descriptive statistics and a binary logistic regression was used to determine the dependence between the variables. A total of 124 patients with sickle cell disease were enrolled; 64 were male and 60 female, giving a sex ratio of 0.93. The rate of post-operative complications was 23.4% (29/124) and the death rate was 3.2% (4/124). The female subjects had more complications than the male subjects p < 0.05. The number of vaso-occlusive crises experienced per year showed a significant impact on the occurrence of post-operative complications p < 0.05. Laparoscopic surgery had fewer post-operative complications 5/46 (10.9%) than laparotomy 14/43 (32.5%). The surgical technique for the abdominal procedures had a significant impact on the occurrence of post-operative complications p < 0.05. The type of surgery (p = 0.198) and the anaesthesia technique (p = 0.225) did not show a significant impact on the occurrence of post-operative complications. Particular attention should be paid to female patients with sickle cell disease as they are more likely to experience post-operative complications, as well as to the frequency of vaso-occlusive crises, which are also predictive of post-operative complications. Opting for laparoscopic surgery whenever possible would help to reduce post-operative complications.

【 授权许可】

Unknown