High Blood Uric Acid Is Associated With Reduced Risks of Mild Cognitive Impairment Among Older Adults in China: A 9-Year Prospective Cohort Study

Frontiers in Aging Neuroscience

Feng Lu¹  Zuyun Liu²  Jiaonan Wang³  Xiaoming Shi³  Heng Gu⁴  Chengcheng Li⁴  Yuan Wei⁴  Feng Zhao⁴  Saisai Ji⁴  Chen Chen⁴  Yuebin Lv⁴  Yingchun Liu⁴  Jinhui Zhou⁴  Xingqi Cao⁵  Xueqin Li⁵  Zhaoxue Yin⁶ 

[1] Beijing Municipal Health Commission Information Center, Beijing Municipal Health Commission Policy Research Center, Beijing, China;Center for Clinical Big Data and Analytics, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China;Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China;China CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing, China;Department of Big Data in Health Science, School of Public Health, Zhejiang University School of Medicine, Hangzhou, China;Division of Non-communicable Disease and Healthy Ageing Management, Chinese Center for Disease Control and Prevention, Beijing, China;

关键词: uric acid;    mild cognitive impairment;    cognitive function;    older adults;    prospective cohort study;   

DOI  :  10.3389/fnagi.2021.747686

来源: DOAJ

【 摘 要 】

Background: It remains unsolved that whether blood uric acid (UA) is a neuroprotective or neurotoxic agent. This study aimed to evaluate the longitudinal association of blood UA with mild cognitive impairment (MCI) among older adults in China.Methods: A total of 3,103 older adults (aged 65+ years) free of MCI at baseline were included from the Healthy Aging and Biomarkers Cohort Study (HABCS). Blood UA level was determined by the uricase colorimetry assay and analyzed as both continuous and categorical (by quartile) variables. Global cognition was assessed using the Mini-Mental State Examination four times between 2008 and 2017, with a score below 24 being considered as MCI. Cox proportional hazards models were used to examine the associations.Results: During a 9-year follow-up, 486 (15.7%) participants developed MCI. After adjustment for all covariates, higher UA had a dose-response association with a lower risk of MCI (all Pfor  trend < 0.05). Participants in the highest UA quartile group had a reduced risk [hazard ratio (HR), 0.73; 95% (CI): 0.55–0.96] of MCI, compared with those in the lowest quartile group. The associations were still robust even when considering death as a competing risk. Subgroup analyses revealed that these associations were statistically significant in younger older adults (65–79 years) and those without hyperuricemia. Similar significant associations were observed when treating UA as a continuous variable.Conclusions: High blood UA level is associated with reduced risks of MCI among Chinese older adults, highlighting the potential of managing UA in daily life for maintaining late-life cognition.

【 授权许可】

Unknown