Clinical value of linked color imaging endoscopy in auxiliary diagnosis of Helicobacter pylori infection

Di-san junyi daxue xuebao

LIN Yuxuan¹  LIU Liu1²  LUO Xiapeng² 

[1] Second School of Clinical Medicine, Southern Medical University, Guangzhou, Guangdong Province, 510280, China ;Department of Gastroenterology, Nanhai Hospital, Southern Medical University, Foshan, Guangdong Province, 528200;

关键词: linked color imaging;    endoscopy;    diagnosis;    helicobacter pylori;    infection;   

DOI  :  10.16016/j.1000-5404.202011187

来源: DOAJ

【 摘 要 】

Objective To investigate the diagnostic value of blue laser linked color imaging (LCI) technology in assistance of detecting infection of Helicobacter pylori (Hp). Methods A total of 120 patients with positive results of 13C-urea breath test (13C-UBT) and 120 individuals with negative results admitted to the Nanhai Hospital due to upper digestive tract symptoms during October 2018 and December 2019 were recruited in the study. Then they were further divided into the study subgroup (undergoing gastroscopy using LCI) and control subgroup (white light imaging, WLI), respectively, with 60 subjects in each subgroup. Their gender, diagnosis under endoscopy, Hp infection by endoscopic evaluation, result of rapid urease experiment (RUT) and immunohistochemical assay were studied and compared among the groups and subgroups. Results There were no significant differences in age, gender and proportions of the diseases diagnosed under endoscopy between the study group and control group (P>0.05). The positive rates of Hp infection evaluated by LCI combined with RUT and immunohistochemical assay were significant higher than those from the WLI subgroup (positive group: 93.3% vs 80.0%, 90.0% vs 75.0%; negative group: 27.9% vs 13.3%, 26.7% vs 11.7%, P < 0.05). For the positive patients with chronic atrophic gastritis (CAG), they had significantly higher positive rate of RUT assessed by LCI than by WLI (75.0% vs 30.8%, P < 0.05). Furthermore, they also had obviously higher positive rates when combined with RUT and immunohistochemical assay than only undergoing simple LCI in positive group and subgroup of chronic non-atrophic gastritis (CNAG) (P < 0.05). Conclusion Targeted biopsy guided by LCI for RUT or pathological examination can significantly improve the positive rate of Hp detection, especially to the CAG patients. LCI technology can reduce the risk of gastric neoplasm, and is worthy of promotion in clinical practice.

【 授权许可】

Unknown