Increased Frequency of Myeloid-Derived Suppressor Cells in Myasthenia Gravis After Immunotherapy

Frontiers in Neurology

Yan Wang¹  Gan Zhao²  Caixia Su²  Ying Wang⁴  Sushan Luo⁵  Chongbo Zhao⁵  Jun Lu⁵  Jianying Xi⁵  Chong Yan⁵ 

[1] Central Lab, Huashan Hospital, Fudan University, Shanghai, China;China Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai, China;Department of Neurology, Huashan Hospital, Fudan University, Shanghai, China;Department of Pharmacy, Huashan Hospital, Fudan University, Shanghai, China;Huashan Rare Disease Center, Shanghai, China;

关键词: myeloid derived suppressor cell (MDSC);    myasthenia gravis (MG);    Arginase-1;    interferon γ (IFN- γ);    immunoregulatory;   

DOI  :  10.3389/fneur.2022.902384

来源: DOAJ

【 摘 要 】

Myeloid-derived suppressor cells (MDSCs) are a population of myeloid progenitor cells with immunoregulatory functions and their role in myasthenia gravis (MG) was unknown. In this study, we investigated the phenotypic and functional alterations of MDSCs in MG before and after immunotherapy. The frequency of MDSCs significantly increased and negatively correlated to that of Th1 or Th17 cells after immunotherapy. MDSCs from untreated patients with MG showed an impaired suppression of IFN-γ production in T-cells and improved immunosuppressive function was identified after immunotherapy. The MFI of Arg-1 in MDSCs also increased after immunotherapy. These findings suggested the functional difference in MDSCs before and after immunotherapy, and MDSCs might play a role in disease remission.

【 授权许可】

Unknown