Ruminant Milk-Derived Extracellular Vesicles: A Nutritional and Therapeutic Opportunity?

Nutrients

Stephen Haines¹  Cherie Blenkiron²  Janos Zempleni³  Alejandra Acevedo-Fani⁴  Juliana A. S. Leite⁴  Rachel C. Anderson⁵  Mark J. McCann⁵  Siew Ling Ong⁵ 

[1] Beyond Food Innovation Centre of Excellence, AgResearch Ltd., Lincoln 7674, New Zealand;Department of Molecular Medicine and Pathology, Faculty of Medical and Health Sciences, University of Auckland, Auckland 1051, New Zealand;Department of Nutrition and Health Sciences, University of Nebraska-Lincoln, Lincoln, NE 68583, USA;Riddet Institute, Massey University, Palmerston North 4442, New Zealand;Smart Foods Innovation Centre of Excellence, Te Ohu Rangahau Kai, AgResearch Ltd., Massey University Campus, Palmerston North 4410, New Zealand;

关键词: milk;    extracellular vesicle;    exosome;    ruminant;    MISEV;   

DOI  :  10.3390/nu13082505

来源: DOAJ

【 摘 要 】

Milk has been shown to contain a specific fraction of extracellular particles that are reported to resist digestion and are purposefully packaged with lipids, proteins, and nucleic acids to exert specific biological effects. These findings suggest that these particles may have a role in the quality of infant nutrition, particularly in the early phase of life when many of the foundations of an infant’s potential for health and overall wellness are established. However, much of the current research focuses on human or cow milk only, and there is a knowledge gap in how milk from other species, which may be more commonly consumed in different regions, could also have these reported biological effects. Our review provides a summary of the studies into the extracellular particle fraction of milk from a wider range of ruminants and pseudo-ruminants, focusing on how this fraction is isolated and characterised, the stability and uptake of the fraction, and the reported biological effects of these fractions in a range of model systems. As the individual composition of milk from different species is known to differ, we propose that the extracellular particle fraction of milk from non-traditional and minority species may also have important and distinct biological properties that warrant further study.

【 授权许可】

Unknown